Not if you keep it long enough in the US (at least one year). As least as far as duty and GST goes, you'll have to re-register it, transfer the title and meet the import requirements:
www.riv.ca which usually means you have to fiddle with the headlights.
If you can't keep it in the US for one year, the best idea is to buy a car made in N America as it will be exempt from duty under NAFTA. But you may get hit with sales tax.
Steve.